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2011 Jan
Handb Exp Pharmacol 196:369405 Holme JA, Hongslo JK, Bjrge C, Nelson SD (1991) Comparative cytotoxic effects of acetaminophen ( N -acetyl- p -aminophenol), a non-hepatotoxic regioisomer acetyl- m -aminophenol and their postulated reactive hydroquinone and quinone metabolites in monolayer cultures of mouse hepatocytes
Don't assume the new vial is the same concentration as the old one
If Phase 3 results are positive and a regulatory dossier is submitted, the MHRA would conduct an independent review of the evidence before any approval could be granted
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