Semaglutide can interact with other medications, particularly those that affect blood sugar or gastric motility
Cui SS, Feng XB, Zhang BH, Xia ZY, Zhan LY (2020) Exendin-4 attenuates pain-induced cognitive impairment by alleviating hippocampal neuroinflammation in a rat model of spinal nerve ligation
There are often side effectsthe most common for semaglutide and liraglutide are diarrhea, vomiting, and nausea
For example, GLP-1 (736) has been shown to inhibit cell death processes in cholangiocytes,15 neurons,16 and pancreatic beta cells.17,18 A combination of antiapoptotic and antinecrotic effects has been reported in pancreatic beta cells.19 Such a cytoprotection appears to be due to the direct preservation of mitochondria, as studies in hepatocytes show that GLP-1 (736) exerts insulin-like effects through the modulation of oxidative phosphorylation and the inhibition of oxidative stress.20 A wide variety of cardiovascular actions of GLP-1 have been reported to date, including hemodynamic system changes.21,22 Specifically, cytoprotective actions of GLP-1 (736) have been reported in the heart.2124 In this regard, the fact that different studies show the presence of GLP-1R in the myocardium of different animal models25,26 and in human cardiac tissue27 suggests that GLP-1 (736) may have direct effects on the heart
