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Start low, monitor response over several days (not hours), and adjust slowlythis mirrors the way dose escalation is approached in Phase 1 trials where uncertainty is high and safety is the priority
Gke, R
The QDD program is similar to CAL, as this program uses a computer-based model to flag applications that are likely to be approved and have easily accessible medical evidence
For others without these conditions, scrutiny should be placed on the risk analysis and factors such as cost, availability, sustainability, long-term effects, and exit costs should be evaluated
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