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How the 1999 Ghrelin Discovery Reframed the Target A conceptual shift arrived in December 1999, when Kojima and colleagues at Kurume University identified ghrelin, a 28-amino-acid acylated peptide predominantly produced by gastric X/A-like cells, as the endogenous ligand for GHS-R1a

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The medication creates a window of opportunity by reducing hunger, but your food choices and movement habits still matter