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Figure 1 Literature search strategy and study selection criteria In 2025, a comprehensive literature search was conducted across multiple electronic databases, including Google Scholar, PubMed, SpringerLink, Elsevier ScienceDirect, and Web of Science, to identify relevant studies published between 2015 and 2025

Increases in resting heart rate are a recognised class effect of incretin-based therapies and have been reported with GLP-1 receptor agonists more broadly, as reflected in the Summary of Product Characteristics (SmPC) for licensed agents such as semaglutide (Wegovy) and liraglutide (Saxenda)

This extends shelf life slightly