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The risk of muscle loss is particularly pronounced in certain populations: older adults (age 65+) who already face age-related sarcopenia, sedentary individuals without resistance training stimulus for muscle preservation, and patients losing weight very rapidly

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Although CntA/B may be responsible for some TMA formation by -proteobacteria intimately associated with the intestinal epithelium using oxygen that diffuses into the luminal content, because of its oxygen requirement, it is unlikely to be the primary physiologic source of l-carnitineTMA activity in the mostly anoxic luminal intestinal environment

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