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Formal pharmacokinetic studies require FDA-regulated clinical trials with standardized protocols, validated assays, and adequate sample sizes
10.1016/j.tem.2015.11.007 Summary Keywords chronic constipation, chrono-nutritional timing, enteroendocrine signalling, gastrocolic reflex, gut brain axis, personalized nutrition Citation Ribichini E, Scalese G, Mocci C, De Amicis N and Severi C (2026) Dietary strategies for chronic constipation: smartly targeting hormonal and reflex pathways for optimal recovery
Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, et al
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