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Mechanistic studies suggest that the potential direct cardiovascular benefits of SGLT2i include augmentation of signal transducer and activator of transcription 3 (STAT3), inhibition of sodium hydrogen exchange (sodium-hydrogen antiporter 1 [NHE-1]), improved mitochondrial metabolism, modulation of natriuretic peptides, improved vascular stiffness and autonomic tone, reduction of inflammation, and improved cardiac energetics

The second is invisible: the downstream cost of outcomes that don't hold

10.1161/01.STR.17.2.196 Stroke 91 SekerdagE.SolarogluI.Gursoy-OzdemirY

Additionally, it slows down digestion, curbs appetite, and aids in lowering blood sugar levels post-meals