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The most important function of ApoA-I is the activation of LCAT, an enzyme that converts free cholesterol on lipoproteins to cholesterol ester (CE)
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Understanding why that combination is compelling requires first understanding what menopause actually does to the body at the cellular level, and why the consequences are so far-reaching, extending well beyond the symptoms that have historically defined how this transition is understood and treated
The NLR family pyrin domain-containing 3 (NLRP3) inflammasome complex recognizes microbial and oxidative stress signals, such as PAMPs, ROS, and DAMPs, through its PRR
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