eli lilly & co s tirzepatide releases Zepbound® (tirzepatide) single-dose vials, expanding supply and access for adults living with obesity FDA approves Eli Lilly's tirzepatide

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5.2 Discontinuation Is the Binding Constraint Roughly 20% of patients discontinue GLP-1 therapy early and another 32% discontinue later in their treatment course, meaning more than half of patients who start semaglutide or tirzepatide are no longer on drug a year later

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1: Your dose may be too low The single most common reason semaglutide appears to stop working is that the patient is sitting at a sub-therapeutic dose for too long