Once the primary visceral (intra-abdominal) fat depots are saturated, free fatty acid spillover into non-adipose tissues and begin to accumulate in ectopic fat depots (liver, skeletal muscle, heart, pancreas, kidney, bone marrow, and central nervous system (CNS) which leads to lipotoxicity, inflammation, and ultimately B-cell dysfunction [64,65,66,67,68,69,70,71]
Factors That Influence Your Personal Weight Loss Speed Your starting weight is one of the strongest predictors of early loss volumepeople starting at higher weights often see faster initial drops (5-10 lbs in month 1) because larger calorie deficits occur naturally
Le Prell et al., 2007b
In der Forschungsliteratur wird dieses schmale Profil als "sauberes" oder selektives Sekretagogum-Verhalten bezeichnet und gilt als das definierende Alleinstellungsmerkmal der Substanz