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Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons

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reported that iron stimulation induces osteoclastic differentiation and bone resorption by activating the NF-B signaling pathway through the generation of ROS, suggesting that ROS is a key mediator of osteoclast activity ( Figure 4 ), the precise role of ferroptosis in RANKL-induced osteoclast differentiation remains unclear and warrants further investigation