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Furthermore, while only macroscopic volumetric variations can be safely assessed in brain tissue with conventional MRI, diffusion tensor imaging (DTI) studies, a more recent development of MRI with increased resolution to visualize fiber bundle structure in WM, have shown that WM volume changes parallel structural alterations in specific WM axon bundles connecting PFC to brain circuits involved in reward and emotion regulation (Schulte et al., 2010) or that, even when macrostructural changes are not patent, there could be significant microstructural disturbances of axon bundles (Pfefferbaum and Sullivan, 2002)
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