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In the global TRIUMPH-4 trial, adults with obesity and knee osteoarthritis treated with the highest dose of retatrutide lost an average of 28.7% of their body weight over 68 weeks roughly 32 kg per patient while also showing marked improvements in pain and physical function related to osteoarthritis
In AD, for example, inflammation exacerbates amyloid-beta accumulation and tau hyperphosphorylation, thereby worsening neuronal damage
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