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Unlike tissue-focused peptides such as BPC-157 and TB-500, or genomic and matrix-remodelling peptides such as GHK-Cu, retatrutide operates as a hormonal receptor agonist targeting the systemic neuroendocrine regulation of metabolism
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Indeed, studies have documented increases in sex hormone-binding globulin (SHBG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) in men treated with GLP-1 RAs, suggesting a relief of metabolic inhibition on the pituitary-gonadal axis
Key outcome measures included the latency to find the platform during training and the time spent in the target quadrant during probe trials, which are indicators of spatial memory retention [2]
