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So its actually fairly easy for them to figure out what kind of budget impact this will have on their bottom lines, and how much they need to raise premiums to make up the difference

The FDA shortage designation for semaglutide and tirzepatide - which originally provided the regulatory basis for much of the compounded GLP-1 market - has been resolved, and the FDA has proposed excluding semaglutide, tirzepatide, and liraglutide from the 503B bulks list after stating it did not identify a clinical need for outsourcing facilities to compound those drugs from bulk substances

(15-19) Liraglutide was found to improve bone microarchitecture and restore bone mass in rats with diabetic osteoporosis, as evidenced by upregulation of Wnt/-catenin signaling and suppression of RANKL expression, leading to increased OPG and osteocalcin levels