Injection site reactions, including redness, bruising, or mild swelling, were also reported but were generally transient
Conclusion Published clinical trial data paints a consistent picture of the retatrutide adverse event profile and associated risks: GI events are common, dose-dependent, and generally transient , with rates comparable to other GLP-1 class compounds
1 Although it was found to lower the risk of worsening heart failure in patients with heart failure with preserved ejection fraction and obesity in the SUMMIT trial (NCT04847557), tirzepatide has not been compared directly with semaglutide for this indication or at all for reducing the risk of MACE in patients with T2D
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