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But since peptide coupling agents are described as immune sensitizers, it stands to reason that the risk even if its small exists for everyone.18 Copper peptide uglies Anecdotal reports suggest that some people may experience worsened skin aging, instead of anti-aging, after using products with GHK-Cu, a rare concern dubbed copper peptide uglies. While this isnt necessarily a safety issue, it is a (again, rare) potential negative effect of using copper peptide products

Replacing an acidic side chain with the basic guanidino group of arginine reverses the local charge and disrupts the interaction

Compounds ranked 29 at 10 M did not exhibit adjuvant activity, suggesting that they did not sufficiently enhance metabolic activity to enable sensitization (Supplementary Fig

We just don't know until there's a true 1:1 comparison and less conflicted research