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Ex-4 binds to receptors on pancreatic -cell, activating adenylyl cyclase (AC) and cAMP, which in turn activate PKA and Epac [33]
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The storage and handling of compounded formulations can also affect potency and consistency, which may influence how the medication affects various body systems
therefore, calcium supplementation is not currently prescribed for the prevention or treatment of metformin-induced vitamin B 12 deficiency (145)
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