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From these data, it appears that the change in metformin pharmacokinetics with aging is primarily accounted for by a change in renal function
N Engl J Med 373:21172128 Neal B, Perkovic V, Mahaffey KW, de Zeeuw D, Fulcher G, Erondu N, Shaw W, Law G, Desai M, Matthews DR (2017) Canagliflozin and cardiovascular and renal events in type 2 diabetes
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