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Samland CJ, Musser RE, Peters JK, Sawyer JT, Owen KQ, Davis DL

Bottom line: Vitamin C is safe for both topical and internal use, but starting with a moderate supplement dose and a dedicated lip-safe topical product is the best way to avoid irritation

Viechtbauer, 2010), employing a random-effect model via the metafor R package ( 3 Results 3.1 Study selection and characteristics The search strategy identified 2,183 potential articles: 1,299 from PubMed, 353 from Scopus, 527 from Embase, 4 from manual screening