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Liver markers (ALT, AST) in extended high-dose protocols

7-HMR also lowered the levels of proinflammatory mediators: brain tissue analyses revealed decreases in TNF- and iNOS (inducible nitric oxide synthase) with 7-HMR therapy (62)

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[1] Elongation of telomeres by epitalon was sufficient to surpass the Hayflick limit in a cell culture of human fetal fibroblast cells, extending their proliferative potential from termination at the 34th passage in the control cell population to beyond the 44th passage in the treated cell population, while increasing the lengths of their telomeres to levels comparable to those of cells in the original culture