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Unlike traditional short-chain peptides that exhibit rapid enzymatic degradation in biological matrices, Dihexa was structurally engineered with an N-terminal hexanoyl chain and modified peptide bonds to enhance metabolic stability and cellular permeability during preclinical research
The study design did not include a control group of post-bariatric patients not using semaglutide for comparison
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Efficacy and safety of glucagon-like peptide-1/glucagon receptor co-agonist JNJ-64565111 in individuals with obesity without type 2 diabetes mellitus: a randomized dose-ranging study
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