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Several miRNAs are known to enhance insulin production, reduce beta cell loss and/or promote beta cell proliferation, such as miR-30d (via increased insulin gene expression) and miR-375 (mechanism unclear) [27]
Treating obesity in type 1 diabetes mellitusreview of efficacy and safety
The pivotal SURPASS clinical trial programme, which evaluated tirzepatide's efficacy and safety, did not identify night sweats as a frequent or significant adverse event
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Figure 1B shows an overview of the preclinical study design with healthy and T2DM subjects
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