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Low glutathione levels are found in people with lupus, rheumatoid arthritis (RA), Crohns disease (IBD), multiple sclerosis (MS), and psoriasis.[ref] Related articles: Lupus, Rheumatoid arthritis, IBD, MS, and psoriasis genes Cystic fibrosis: People with cystic fibrosis, which is a genetic disease caused by mutations in the CFTR gene, have frequent respiratory infections that cause lung inflammation and produce oxidative stress in the lungs, which depletes glutathione levels
The conversion of GSSG back to GSH during ROS production would explain the unbalanced activation of the glutathione oxidation/reduction cycle
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Alcohol activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells
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