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2 Immune cell mitochondrial dysfunction mechanisms in the perioperative period The perioperative period represents a convergence of multiple physiological stressorsincluding tissue ischemiareperfusion, mechanical injury, anesthesia exposure, and neuroendocrine surgesthat collectively challenge immune cell homeostasis at the mitochondrial level

they can compromise the structure and function of the cell membrane, reducing its stability, causing the loss of intracellular substances, and further disrupting the normal physiological functions of the cell

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