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To enhance interpretability despite this variability, we pooled outcomes within instruments (HDRS, BDI, MADRS), conducted prespecified subgroup analyses by comparator group and age, used random-effects models, performed leave-one-out sensitivity analyses and publication-bias diagnostics, and applied meta-regression to examine treatment duration and daily dose
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That work led to the discovery of glucagon-like peptide-1 (GLP-1), a hormone released from the small intestine that helps control insulin secretion, slow digestion and reduce appetite
