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GPX4 or its upstream regulatory factor Nrf2, when sumoylated, can downregulate the intracellular ROS levels[95], or SLC7A11 induced by SENP1 expression[68], both of which can limit the development of ferroptosis

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Nanotechnology offers innovative strategies to enhance ICB by improving drug delivery, amplifying ICD, and reprogramming the TME

- 5-Amino-1MQ is studied in research models involving NNMT pathway activity, NAD+-adjacent metabolism, adipocyte biology, methylation-related signaling, cellular energy regulation, and body-composition pathway research