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For example, adalimumab as a TNF inhibitor blocks the bind of TNF and its receptors to reduce cytokines (like MMP-1 and MMP-3)-driven inflammatory processes, which suppresses the destruction of cartilage and bone ( Figure 1 On the other hand, several cytokines, including IL-4, IL-10, IL-13, and TGF-, exert anti-inflammatory effects in RA

These compounds also provide neuroprotective effects that may help manage chronic stress responses in damaged tissues

Subcutaneous injection at the site of injury (locally) or into abdomen/thigh (systemically)

Every additional compound in a stack adds another opportunity for an impurity or a sterility failure near a healing incision