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Pen Dosage Chart Dosage & Protocols Variations Standard Research Protocol Dose: 1.0 5.0 mg (= 20100 clicks) Duration: 3 consecutive days Frequency: Once every 2 weeks (intermittent pulse) Cycle Interval: 2 4 weeks off before repeating Goal / Description: Baseline senolytic pulsing observed in preclinical aging models
The method of injection, which can be either intramuscular (IM) or subcutaneous (SC), determines the appropriate needle gauge and length
The first incorporates GSH into the mitochondria by inorganic phosphate exchange and the second by exchange of 2-oxoglutarate (Figures 2, 4)
Caja L, Dituri F, Mancarella S, Caballero-Diaz D, Moustakas A, Giannelli G, Fabregat I (2018) TGF- and the tissue microenvironment: relevance in fibrosis and cancer
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