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iDC expresses two active histamine receptors, H1 and H2, and stimulation by LPS and simultaneous administration of exogenous histamine can act on H2 receptors for a short period of time, increasing IL-10 production and decreasing IL-12 secretion, and ultimately polarizing CD4 + T cells to a Th2 phenotype (100)
Certainty of evidence All primary and secondary outcomes were judged to have high certainty of evidence across all GRADE approach [11] domains, including risk of bias (D1), inconsistency (D2), indirectness (D3), imprecision (D4), publication bias (D5)
This interaction has been theorized to activate intracellular cyclic AMP pathways, leading to downstream transcriptional and secretory responses
(28) Quinine Scientific name Cinchona calisaya
