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Unlike full-length human growth hormone, which binds to growth hormone receptors throughout the body and triggers widespread effects, AOD-9604 acts primarily on adipose tissue through a distinct receptor mechanism

AOD9604 and Energy Balance Research In obese ob/ob and lean C57BL/6J mice treated for 14 days via mini-osmotic pumps, AOD9604 significantly reduced body weight gain in obese mice, associated with increased in vivo fat oxidation and increased plasma glycerol levels as an index of enhanced lipolysis without the hyperglycaemia or reduced insulin secretion associated with intact hGH treatment

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November-December 2020