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2.3 The therapeutic and protective potential of piperine PPR, the bioactive alkaloid in black pepper ( Piper nigrum ), undergoes extensive metabolism in enterocytes and the liver, where glucuronidation, sulfation, and methylation produce water-soluble derivatives for excretion (27)

24 Certain mutations paradoxically correlate with ICI resistance despite elevated TMB, highlighting the importance of antigen presentation, mutation type, and immune contexture

One common disadvantage of exosomes is their random movement in vivo and lack of specific targeting

First-pass splanchnic metabolism of dietary cysteine in weanling pigs