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Tirzepatide carries a boxed warning for thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
They inhibit both COX-1 (associated with GI protection) and COX-2 (associated with inflammation)
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More on this topic Many doctors worldwide have voiced concerns about the drugs
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