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Taken as a once-daily tablet, it functions by improving the body's ability to control blood sugar helping the pancreas release insulin when levels are high, lowering the amount of sugar the liver produces, and slowing digestion so blood sugar rises more gradually after meals

Additionally, tirzepatide may affect the absorption of oral medications due to delayed gastric emptying, which is relevant for drugs with narrow therapeutic windows

Collectively, these novel therapeutic venues for the treatment of melanoma have improved overall survival

In an as-treated (AT) analysis, follow-up was also censored at study-drug discontinuation or comparator-initiation