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Dysregulated NLRP3 produces pro-inflammatory cytokines, IL-1 and IL-18, which serve to exacerbate myocardial damage initiating widespread inflammation within the cardiac tissue The activation of the NLRP3 inflammasome is related to several high-risk factors of DCM such as hyperlipidaemia, diabetes, obesity and hyperhomocysteinemia (100)
Preclinical research has demonstrated protective and healing effects on gastric mucosa, intestinal tissue, and esophageal damage
injection of CNO or saline
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