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Lysergic acid diethylamide (LSD), a partial agonist of the 5-HT2A receptor, has been shown to induce coordinated remodeling of mitochondrial bioenergetics and cellular proteostasis in human cerebral organoids, implicating mitochondrial regulation in psychedelic-induced neuroplasticity [139]
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Its stability in vitro is limited, with a half-life of roughly 15 minutes, but in vivo it may form complexes with carrier proteins or exist as part of a larger precursor molecule to resist degradation
Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats
