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demonstrated the role of positive allosteric modulators such as alprazolam to augment and/or prolong GABA actions ( 5 Clinical studies using GABA in diabetes 5.1 GABA and GABA/GAD65-alum clinical trial in children with recent onset T1D The GABA and GABA/GAD65 trial (82) was the first human, prospective, double blind, placebo-controlled and randomized clinical trial of oral GABA (with and without GAD65-alum) in new onset type 1 childhood diabetes

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