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Digestive side effects are common early on, and supervision matters most for protecting muscle and preventing early dropout, which is often costlier than the medication itself.

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For example, in the case of amylin biology, significant translational gaps between rodent and human systems persist, the optimal receptor selectivity profile for clinical use remains unclear, and molecules continue to advance in clinical development despite these uncertainties ( 3.4 Changing clinical and regulatory expectations Finally, shifts in clinical and regulatory expectations have altered the landscape in which peptide therapeutics are evaluated