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Some patients notice a brief cooling sensation in the arm or a metallic taste, which is normal with magnesium-containing formulas
Therefore, the Food and Drug Administration (FDA) released a guidance requiring all new drugs for glycemic control in T2DM patients to demonstrate cardiovascular safety, a policy that was continued and further emphasized in the 2020 FDA Guidance for Diabetes Drug Development [7, 8]
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We do not have dose-response data to say whether sub-maximal doses of GLP-1 RAs (for example, in patients who do not want or cannot tolerate the full dose) are effective
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