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It plays a well-established role in appetite regulation, blood sugar management, and gastric motility signaling satiety to the brain and influencing how quickly food moves through the digestive system
This is not a supraphysiologic signaling cascade
Based on our results, we propose that the GLP-1/GLP-1R signalling in the OB constitutes a neuronal pathway involved in regulating energy homeostasis
9,10 Additionally, GLP-1 RAs suppress glucagon secretion from the -cells in the pancreas, leading to decreased blood glucose levels
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