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Description

The primary histological endpoint of the month 18 interim analysis (intent-to-treat [ITT], n=931) was improvement in fibrosis 1 stage with no worsening of NASH using the NASH Clinical Research Network criteria

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Adequate fluid intake becomes even more important when cardiovascular effects are a concern

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Patients with chronic gastrointestinal symptoms may also experience rapid weight loss, muscle wasting, fatigue, and worsening nutritional deficiencies over time

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Circumventing the then-standard Boc/Bzl protecting group paradigm, these choices made it possible to avoid using the strong acid anhydrous hydrogen fluoride (HF) for final cleavage of the peptide from the solid support

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