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The PK stability profile in mice of our early fusions such as Ab#2_GLP1 and Ab#2_EX4 demonstrated that the in vivo GLP-1R activity of such peptide-antibody fusion molecules rapidly decreased over time due to peptide degradation compared to the exposure achieved by the antibody Fc component (Fig

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Larger studies are still needed to confirm the benefits of folate supplementation

GLP-1 receptor agonists, such as semaglutide (sold under the brand name Ozempic or Wegovy) and tirzepatide (brand name Mounjaro or Zepbound), are medications originally developed for diabetes and now approved for chronic weight management at specific doses