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GLP-1 agonists initially faced coverage challenges that have progressively improved

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Another group conducted an RCT and analyzed data from the intervention group consuming a Mediterranean-style diet and identified reduced consumption of processed food as the most impactful component for the improvements in depression observed among this group (124)

Future investigation should also clarify whether the benefit is driven by direct antitumor effects of GLP-1 RAs or by indirect mechanisms mediated through weight loss and cardiometabolic risk reduction