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While IGF-1 has insulin-agonistic actions and has been used for treatment of severe insulin resistance, IGF-1 reduction with the GH antagonist pegvisomant improves glycemic control in acromegalic patients with diabetes or impaired glucose tolerance despite elevated GH (35, 36)
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The lowest therapeutic dose is 0.25 mg weekly, and while this is typically used as a starting dose, some people maintain this amount throughout their treatment with great success
also received a research grant from Gilead for fatty liver research
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