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Colonic Insl5 and plasma INSL-5 levels are elevated during fasting in calorie-restricted mice and normalize upon refeeding (164)
By improving liver function and fat transport, and supporting energy production through B12, they can make an active, calorie-controlled lifestyle more effective
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The strongest evidence for DSIP comes from small (n under 50), mostly 1970s to 1990s European studies
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