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Impaired L-carnitine synthesis by the kidneys may also contribute to the potential for carnitine deficiency in patients with end-stage renal disease undergoing hemodialysis
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Despite the low positive rate of the high-throughput screening (0.013%), a series of less potent hit molecules were identified
To enhance the pharmacological properties of the ruthenium catalyst, provide cancer selectivity for the treatment, and enable the treatment of challenging hypoxic tumors, the metal complexes were covalently conjugated to the side chains of polymers with a carbon fluorinated moiety that could co-deliver oxygen to the tumor
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