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Traditionally GLP-1(9-36) was considered inactive, however more recent studies indicate that GLP-1(9-36) can contribute to inhibiting glucagon secretion by inhibiting voltage-gated calcium channels through a GPCR mechanism, an effect which reduces the number of glucagon containing vesicles that are available for exocytosis, thereby contributing the the decrease in glucagon secretion (Figure 1)(Zheng et al, 2024)

Patience and adherence to the prescribed injection schedule are essential for optimal outcomes

So what would a more thoughtful approach look like

The Precision Peptide Genetic Test (available for $298) can identify genetic predispositions in your GIPR, FTO, and MC4R pathwaysinforming whether you are a strong responder to GLP-1 therapy or may benefit from dual-compound approaches