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35 KrishnaS.WhiteN
Given the frequent overlap among clinical phenotypes, the choice of therapy should arise from a shared decision-making process between clinician and patient, prioritizing the most clinically relevant complication and the most meaningful one to the individual
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The main barriers are bioavailability (how much drug actually enters the bloodstream), stability (peptides degrade when exposed to skin temperature and enzymes), and patient compliance (patches still require weekly changes and site monitoring)
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