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The catch is that this internal supply chain slows down with age, stress, and poor diet, which is exactly why glutathione levels start dipping over time

Our analysis clearly demonstrated that DMSO cannot be considered biologically inert but induces large alterations in microRNAs (miRNA) and epigenetic landscape, especially in the maturing cardiac model

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165 Biotransformation pathways may generate active metabolites that enhance or reduce efficacy or cause off-target toxicity